As the development of nanotechnology continues to expand, it is essential to determine the toxicity of nanoparticles. The coating agents of nanoparticles determine their shape and size, stabilize the nanoparticle, and enable them to be useful for biomedicine applications. These coating agents must also be considered for toxicity studies of the nanoparticles since they are an integral part of the nanoparticles. In this experiment, we report the cytoxicity of two commonly used coating agents, cetyltrimethylammonium bromide and hexadecylamine, on human epidermal (HaCaT) cells by MTS Assay and Trypan Blue staining. We found that with 2 hour exposure, cetyltrimethylammonium bromide is toxic at 100 �M, and hexadecylamine is not toxic. For 24 hour exposure, cetyltrimethylammonium bromide is toxic at 30 �M and hexadecylamine is toxic at 100 �M.

Cytotoxicity of nanoparticle coating agents hexadecylamine and cetyltrimethylammonium bromide to human skin cells

247th National Meeting (2014)

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