The lack of selectivity and sufficient delivery of anticancer agents is the major cause of severe side effects and treatment failures. Inorganic layered nanomaterials are an attractive candidate for drug delivery applications due to their high ion exchange capability which can be exploited to encapsulate different types of drugs. Once the drug is encapsulated, it is isolated and can be delivered to tumor cells , avoiding normal healthy tissue and hence preventing some of the side effects of chemotherapy.  We have designed and synthesized novel nano vessels composed of zirconium phosphate (ZrP), an inorganic layered nanoparticle, which has been loaded with doxorubicin (DOX), a common drug utilized in cancer treatment.  The particles were �sugar coated� in order to improve the biocompatibility, solubility, and transport of the nanoparticles in the body. The DOX loaded ZrP nanoparticles (DOX@ZrP) were surface modified with calcium ions, via an ion exchange reaction with the protons on the surface at the phosphate groups, followed by the complexation of the calcium layer with D-Glucopyranose 6-phosphate. The nanoparticles were characterized by thermogravimetric analysis (TGA), infrared spectroscopy (IR), and X-ray powder diffraction (XRDP), transmission electron microscopy (TEM), UV-vis spectroscopy, among other techniques.  The full description of the synthesis and characterization of the sugar-coated ZrP will be presented.

Sugar-coating of doxorubicin loaded inorganic layered nanomaterials for drug delivery in cancer nanotherapy

247th National Meeting (2014)

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