Nanoscale metal organic framework particles (NMOF) are nanoparticles composed of an amorphous framework constructed from an organic linker ligand and a metal ion. These nanoparticles are excellent candidates for use in drug delivery due to their biodegradability, tunable size and high loading capacity. In this study, we synthesized novel NMOFs based on the anti-cancer drug cisplatin with high payload (83%). A targeted near-infrared (NIR) molecular probe was also incorporated into this nanoparticle to achieve NIR imaging capability and targeted drug particle delivery. The anticancer effect of the nano-construct was demonstrated on cancer cells and the targeted delivery of this nano-theranostic agent was evaluated both in vitro and in vivo.

Cisplatin-based metal organic framework nanoparticles for targeted drug delivery and tumor imaging

247th National Meeting (2014)

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