Responsive enzymogels are a novel type of phase-boundary biocatalysts, i.e. they allow remotely directed performance on insoluble substrates (e.g. cellulosic biomass). Responsive biocatalytic enzymogels are designed as core-shell nanoparticles having superparamagnetic core surrounded by grafted responsive polymer brush scaffold (Fig. 1.). The magnetic core can be used for the recovery of enzymogels from the reaction mixture as well as for their translocations to specified locations of the biocatalytic reaction. Responsive polymeric brushes can be loaded with enzymes at pH 4.0 and can release enzymes when the pH is increased to 7. The structure of enzymogels helps to preserve biocatalytic activity of the loaded enzymes. The responsive brush-like architecture of polymeric scaffold allows for the mobility of loaded enzymes and also favors the efficient interfacial interaction with solid substrate. Application of responsive enzymogels can lead to new approaches in remotely controlled biocatalytic reactions in production of biofuels, drug delivery, recyclable biocatalysts, etc.Fig. 1. Responsive enzymogel particle

Nanostructured responsive enzymogel particles for bioconversion

247th National Meeting (2014)

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