The need to simultaneously target and image prostate cancer while providing the means to site-selectively deliver a therapeutic is currently at the forefront of detecting and treating many cancers. This theranostic approach is realised through the use of hyberbranced polymer (HBP) systems whereby the multi-armed polymers allow the incorporation of various modalities within the one system (Figure 1).Figure 1. The schematic structure of a multimodal hyperbranched polymer for prostate cancer targeting, imaging and drug delivery.As imaging modalities, we describe the synthesis of hyperbranched copolymers containing 2,2,2-trifluoroethyl acrylate and a near infrared dye providing the capability for 19F MRI and optical (fluorescence) imaging. Targeting of prostate cancer is focussed on ligands that bind prostate specific membrane antigen (PSMA) and is achieved by comparing three different targeting ligands including a small molecule urea glutamate derivative, a polypeptide and a monoclonal antibody (MAb J591). Targeting and imaging efficiencies were tested both in vitro and in vivo using PSMA positive prostate cancer cells and xenografts. Drug delivery was achieved through a hydrazone linked moiety which was demonstrated to be released at pH 5.5.

Multimodal hyperbranched polymers for simultaneous imaging and drug delivery for targeted prostate cancer theranostics

247th National Meeting (2014)

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