Cyclodextrin (�-Cyd), a derivative of Cyclodextrin, is commonly used as a host molecule. The chemical properties of Cyclodextrin are unique in its ability to form inclusion complexes for a wide range of guest molecules whether solid, liquid or gas by complex. The objective of the study is to implement �-cyclodextrin as the enhancer of water solubility for a tetracycline complex. Tetracycline is not independently soluble in water. Tetracycline is commonly used as an antibiotic and treatment of infections. The compound is made water-soluble by the use of hydrochloric acid. Hydrochloric acid can cause negative side effects within the human body. Biomedical research creates a solution that increases the water solubility of tetracycline by encapsulation into the �-cyclodextrin complex. Within each study and method the control groups independently consisted of the tetracycline and �-cyclodextrin. Physical mixing, kneading, and precipitation methods prepared �-cyclodextrin inclusion complexes containing tetracycline. Nuclear Magnetic Resonance (NMR) Spectroscopy and Scanning Electron Microscope (SEM) was used to analyze the products of synthesis and the phase solubility study tested the solubility of �-cyclodextrin. The NMR analysis of the kneading method complex displayed shifting peaks and removal of hydrogen bonds; the shift in functional groups containing the hydrophobic carbons leads us to conclude that an inclusion was formed with �-cyclodextrin and tetracycline. The SEM imaging of the precipitation method complex exhibited completely contrasting exterior in opposition to the controls �-cyclodextrin and tetracycline surfaces proving interaction between the control compounds. The Phase Solubility Study displayed linear growth; the complex with the greatest mass of �-cyclodextrin dissolved the greatest volume of water and remained with the greatest mass of sediment. The results indicate that �-cyclodextrin increases the water solubility of tetracycline.

Encapsulation of Tetracycline using ?-cyclodextrin

247th National Meeting (2014)

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