Copper catalyzed oxidative coupling reaction of formamides with 2-carbonyl-substituted phenols and �-keto esters provided corresponding carbamates with excellent yields and high stereoselectivity under mild reaction conditions. The reaction proceeded through direct C�H bond activation of formamides. This approach offers ligand, base and toxic phosgene free alternative to the existing methods for synthesis of carbamates. Developed protocol was successfully applied to the single step synthesis of carbaryl insecticide derivative and three novel halogenated carbamates. Mechanistic results for this transformation suggest crucial need of 6.0 equiv. TBHP.

Copper catalyzed synthesis of carbamates by direct C-H bond activation of formamides

247th National Meeting (2014)

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