Since cyanation is a fundamental reaction, its development has been important issue in synthetic chemistry. Our research focus is cyanation of non-activated alkynes catalyzed by transition metal species and reported some unique reactions such as 1,2-dicyanation and dicyanative cyclizations. This presentation will show a new application using allenes and alkynes under Ni catalysis. This protocol provides regio- and stereoselective install of CN and H groups through the connection between above components. 

Nickel-catalyzed cyanation of carbon-carbon triple bonds

247th National Meeting (2014)

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