A series of helical and non helical polypeptides, poly(g-propargyl-L-glutamate (PPLG) and poly(g-propargyl-rac-glutamate (PP-rac-G) respectively, have been synthesized through the ring-opening polymerization of their respective N-carboxyanhydride monomers. Monosaccharides such as mannose and galactose substituents were added to the side chains through copper alkyne/azide cycloaddition reactions. The resulting glycopolypeptides were subjected to turbidity and quantitative precipitation assays to determine both their binding kinetics and binding efficiency to Concanavalin A, a mannose specific lectin. Physical characteristics of the glycopolypeptides such as chain length, backbone conformation and mannose density were systematically varied to enable an assessment of their effects on lectin binding.

Synthesis, characterization, and lectin binding studies on a series of synthetic glycopolypeptides with varying chain lengths, backbone architecture and epitope densities

247th National Meeting (2014)

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