What does �nanotheranostics� mean for biology and medicine? Since their invention, nanoparticles demonstrated both unique properties and an even more unique ability to manipulate energy at nanoscale. Although research into the biological, and especially the medical, applications of nanoparticles will result in entirely new knowledge and medicine, it is yet at the very beginning. In an effort to develop nanotheranostic medicine into true nanomedicine, our lab engaged at nanoscale, the two major life-supporting phenomena, light and heat. Using a mechanism of plasmon resonance in gold nanoparticles, we developed novel, tunable and stealth type nanoprobes, plasmonic nanobubbles (PNBs), tiny vapor bubbles that are generated around gold nanoparticles with short laser pulses. PNBs will provide molecular and cellular imaging, diagnosis, therapy and theranostics (diagnosis and treatment united in one fast procedure) with the speed, selectivity and precision far beyond the limits of modern medicine. Our interdisciplinary research includes three major avenues: fundamental studies of physics, optics and biology of PNBs, studies of PNB-induced bioeffects in cells and organisms, and the development of PNB technologies for cell level imaging, theranostics, surgery, gene therapy and drug delivery.

Cancer cell theranostics rapidly detects and destroys drug-resistant tumors in vivo

247th National Meeting (2014)

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