The purpose of the research was to develop a series of metal-organic frameworks (MOFs), which displayed high potential in delivery drugs and cancer diagnosis. The MOFs were produced via a feasible hydrosolvo-thermal wet-chemistry approach through ligand coordination. Tunable covalent (ligand) coordination frameworks in the fabrication of MOFs allow for high surface area, unique crystal geometry, ultrahigh porosity and controlled particle size. Transition metals centers such as iron (Fe), gold (Au) and platinum (Pt) were used to serve fluorescence platforms whilst the ligands and capping agents served as biocompatibility agents. Several advanced instruments were used to determine the crystalline phase, particle size, distribution, and crystallinity of MOFs. In-vitro toxicity data indicated that MOFs IC50 (0.02 ppm) is comparable to, or lower than the current first-line drug formulations; at higher doses, the kinetics of action were approximately ten-fold higher. These biological effects may be attributed to the unique tetra-topic carboxylate ligand bridging to a bimeric �2-H2O-centered cluster, in addition to high crystallinity and high aspect ratio. The latter factors lend themselves to high MOF-cell surface contact, which in turn leads to high degree of catalysis (e.g. depolarization of the mitochondrial membrane from the lactate dehydrogenase assay and inferred anti-topoisomerase I activity by comparison to SN-38 standard). Collectively, our results demonstrate a potentially viable approach in the treatment of solid tumors.

Functionalized metal-organic frameworks as inhibitor of cell division

247th National Meeting (2014)

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