Zebrafish provide many advantages that include, but are not limited to, the following: 1) fast embryonic development, yielding full organ functionality in a short time frame, 2) a transparent body, providing excellent light penetration for a variety of optical and fluorescence microscopy experiments, and 3) an economical and easy maintenance setup, thereby increasing the possible number of samples in a given experimental group. While such zebrafish-specific advantages confer an ideal model for rapid and large-scale toxicity experiments, zebrafish have only been used by others in a limited manner. In this study, we present the in-vivo nanotoxicity of nanoparticles by conducting a thorough analysis that includes an examination of phenotypic developmental abnormalities, apoptotic cell death, and heart function.

Systematic nanotoxicity evaluation via zebrafish models

247th National Meeting (2014)

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