This research is focused on producing various magnetic nanocomposites (e.g. Fe3O4-based MNCs) via a green bottom-up synthesis approach using natural products as reducing and dispersing agents. The fabrication variables of the green synthesis were optimized to obtain MNCs with tuneable architecture and magnetism. The use of water-soluble Salvia hispanica and traditional Chinese medicine (Cordyceps extracts) offers a variety of water-soluble components to enhance the reduction of inserted noble (such as gold and platinum) metal aimed to increase the fluorescent intensity of those MNCs in a cancer treatment setting. The MNCs were modified, using amphiprotic functionalization and surface grafting chemistries, that successfully maintained high super-paramagnetic behaviour averaged at 60 A�m2�kg-1. Advanced techniques were used to characterise the materials, which demonstrate MNC crystalline structure, uniform paramagnetism and intermediate biological toxicity. The cytotoxicity (cyto) analysis using Chinese hamster ovary (CHO) cells showed an effective dose at 50% of ~20 ppb, (cyto 100 ppm) indicating that amphiproticity of grafted Fe3O4-MNCs would facilitate targeting of tumour cells. All class of MNCs displayed EC50 activity (11-16% relative to control iron oxide) and can serve as targeting and drug delivery systems as demonstrated in vitro by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) (MTT) assay  . The mode of inhibition was not thoroughly investigated but appears to involved inhibition of DNA unzipping and replication, as shown by SN-38 standard anti-cancer drug, used as a baseline for efficacy evaluation.

Evaluation of design and magnetism of nanoparticles and their in vitro cytotoxicity analyses

247th National Meeting (2014)

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