Polypeptide composite particles, PCPs, with a magnetic core and an a-helical homopolypeptide shell have been produced by combining ring-opening polymerization and Huisgen's 1,3-dipolar cycloadition also known as click chemistry. The desired sparse coverage with polypeptide was confirmed by TGA analysis. Shell molecular weights were measured by GPC and MALDI-TOF and their conformation was investigated by FTIR. Other techniques such as XRD, TEM, XPS, DLS and SQUID were used to investigate the nature of the composite particles.PSLG-click hybrid was found to be a good support for lipase from Candida Rugosa immobilization. Suspension of the PSLG-click hybrid particles in a liquid crystal, LC, rodlike PSLG matrix enabled a good control of the clustering under applied magnetic field. Under stress, PCBL-click particles showed shear thinning tendency and behaved as a non-Newtonian stiff material.This work has been supported by Grants DMR-1306262 from the National Science Foundation.

Polypeptide composite particles by click chemistry: Preparation, characterization, and applications

247th National Meeting (2014)

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