Paramagnetic chemical exchange saturation transfer (ParaCEST) agents have exchangeable protons that resonate at a chemical shift that greatly differs from the bulk water signal. They have potential as magnetic resonance imaging contrast agents, offering the ability to saturate the exchangeable protons selectively. A series of Fe(II) chelates and their Co(II) analogs have been examined, in hopes of better understanding the source of the chemical shifts. Temperature-dependent NMR relaxation of ligand protons in both organic and aqueous solution will be presented, along with low-temperature EPR and optical spectra that help elucidate the metal ion's electronic structure.

Magnetic resonance studies of Co(II) and Fe(II) ParaCEST contrast agents

247th National Meeting (2014)

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