Showing activity against cancer, HIV, Alzheimer's disease, inflammation and asthma,1 aryl sulfides are widely used in the pharmaceutical industry. The synthesis of these compounds involves cross coupling of either an aryl or vinyl halide and a thiol. In an attempt to develop catalytic systems for these reactions, a pyridine bis-amido nickel pincer complex was synthesized, characterized and tested for catalytic activity during the synthesis of a diaryl sulfide. Desirable catalytic features include a cheaper metal than the palladium previously used in catalytic systems2 as well as a low catalyst loading than is required by copper catalysts3. Previously, a nickel bis-phosphinite-based pincer complex was developed; however, this catalyst was unstable in the basic conditions required for the synthesis of the diarylsulfide4. This study documents the synthesis of various substituted nickel pincer complexes and their catalytic activity.References :1Eichman, C. C.; Stambuli, J. P. Molecules 2011  , 16, 590-6082Fern�ndez-Rodr�guez, M. A.; Shen, Q.; Hartwig, J. F. J. Am. Chem. Soc. 2006  , 128, 2180-21813Zhu, D.; Xu, L.; Wu, F.; Wan, B. Tetrahedron Lett. 2006  , 47, 5781-57844Zhang, J.; Medley, C. M.; Krause, J. A.; Guan, H. Organometallics 2010  , 29, 6393-6401

Pyridine bis-amido nickel complexes for catalytic cross coupling reactions

247th National Meeting (2014)

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