The synthesis of the bifunctional complex [Ru(tpy)(dppz)(NO2-)]+ (tpy= 2,2';6'2�-terpyridine; dppz = dipyridophenazine) will be reported. This complex contains the strongly DNA intercalating ligand dppz, and the NO2- ligand, which can act as a precursor to nitric oxide under acidic and hypoxic conditions. The complex is being studied for DNA binding, conversion of the nitro ligand to nitrosyl, and reduction to NO and NO-. Solutions mimicking the physiological environment of normal and cancer cells will be used to study the behavior of the complex in the presence and absence of polymeric DNA. Gel electrophoresis will be used to determine if strand scission has taken place. Binding studies of the compound such as the characterization of the binding constant and binding site size, and kinetic data will be also reported.

Reactivity of [Ru(tpy)(dppz)(NO2-)]+ in model physiological conditions with DNA

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.