Seaweeds have a long history of inclusion in the human diet especially in East Asian countries including Japan, Korea and China. Species such as Palmaria palmata (dulse or dillisk) and Chondrus crispus (Irish moss) have a long history of use in Eastern Canada and USA, Ireland, Scotland and Scandinavian countries. Seaweeds are extensively cultivated for the extraction of alginate, agar and carrageenan with wide range of food and industrial applications. They are excellent dietary sources of fiber, protein, minerals, vitamins and various bioactive molecules, and are gaining popularity as health foods in western countries. Our interest in polar lipids resulted from investigating the nitric oxide (NO) inhibitory activity of extracts from P. palmata and C. crispus commercially cultivated on land in Nova Scotia. Galactolipids including both monogalactosyldiacylglycerols and digalactosyldiacylglycerols, lutein, and a few free fatty acids were isolated and identified from C. crispus. Similarly, galactolipids, phospholipid, sulfolipids and phosphatidylglycerols were isolated from P. palmata. All the isolated polar lipids exhibited strong and dose-dependent NO inhibition of lipopolysaccharide (LPS)-induced NO production in macrophage RAW246.7 cells. These lipids were shown to inhibit NO production through down-regulation of inducible nitric oxide synthase (iNOS) expression

Lipids from the red seaweeds <i>Plamaria palmata</i> and <i>Chondrus crispus</i> inhibit lipopolysaccharide-induced nitric oxide production in RAW 246.7 macrophage cells

247th National Meeting (2014)

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Lipids from the red seaweeds Plamaria palmata and Chondrus crispus inhibit lipopolysaccharide-induced nitric oxide production in RAW 246.7 macrophage cells