Acute kidney injury (AKI) is a common cause of morbidity (5-7%) in hospitalized patients with over 50% mortality. AKI is particularly common in patients in intensive care units.  Currently, AKI is diagnosed based on elevations in the level of serum creatinine and blood urea nitrogen; however, they lack required sensitivity for early detection of AKI. Identification of biomarkers for the early detection of AKI is a high priority for patient management and survival. We examined three urine biomarkers proposed to help in early detection of AKI: interleukin 8 (IL-8), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule 1 (KIM-1). Findings indicate that measurement of urine IL-8 and NGAL may identify patients with early AKI on admission to the ICU. Elevated levels of KIM1 in the urine on admission may identify patients at risk for subsequent AKI.

IL-8, NGAL & KIM-1 as early biomarkers for acute kidney injury diagnosis

247th National Meeting (2014)

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