1,3,4-oxadiazole and pyrrole structural motifs were connected using a Schiff base and /or amide groups to investigate the combination of two distinct structural motifs on cancer cell lines. Friedel-Crafts acylation of 2-pyrrolyl carboxylates followed by hydrolysis afforded 4-substituted 2-pyrrole carboxylic acids. Subsequent coupling with 2-amino-1,3,4-oxadiazole derivatives formed the targeted amides. The Schiff bases were formed by the reaction of 2-amino-1,3,4-oxadiazoles with appropriately substituted aldehydes. Preliminary screening of the synthesized compounds for their anticancer potential against a panel of three breast cancer cell lines (MDA MB231, Ishikawa and BT 474cells) at six concentration levels is reported.

Synthesis and anticancer evaluation of pyrrolyl-1,3,4-oxadiazole conjugates characterized by Schiff base and amide linkages

247th National Meeting (2014)

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