Trinity Biotech, Dublin, Ireland has obtained FDA approval for Hb9210 in 2011. This is a method using boronate affinity high performance liquid chromotography to for use in precise HbA1c analysis in less time.  Each unit costs ~ $25,000. Hyperbolic diffusion models have the capability to predict the sigmoidal shape of the break through curves. Parabolic Fick diffusion and hyperbolic damped wave diffusion models are used to predict the elution from the chromotographic column.  Glycation specific binding of boronate affinity is used in the integrated HPLC system for detection of all of teh glycalated Hb species present.  The diabetes testing time of 66 s is less compared with the tests that need prolonged periods of fasting. The analytic column used is aminophenylboronic acid bound to porous polymer support. The glycalation reaction is also taken into account in the model. Different regimes of diffusion and reaction are identified. Based on the models the cost of the unit can be reduced and test optimized.

On comparison of parabolic and hyperbolic diffusion models for use in design of boronate affinity high performance liquid chromotography

247th National Meeting (2014)

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