Developing nanomaterials with dynamic physicochemical properties open new opportunities to control their interactions with biological systems. Here, we used permutations of DNA-coated nanoparticles to construct a library of biodegradable colloidal superstructures displaying distinct physicochemical properties. In vitro screening against a model cell line demonstrates that cellular uptake of superstructures was dependent on both individual nanoparticle design and assembly configuration. Additionally, endosomal internalization of superstructures triggered their rapid degradation into dispersed components, facilitating subsequent extracellular escape in a design-dependent manner. This use of molecular assembly to design nanomaterial-cell interactions provides new possibilities to engineer the biological delivery and clearance of nanocarriers that is not possible using solid nanoparticles.

Impact of DNA assembly on nanomaterial-cell interactions

247th National Meeting (2014)

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