Previous work from our group described development of a guanidinium-functionalized AEX membrane adsorber that exhibits high protein binding capacities as well as excellent tolerance to high ionic strength and multivalent buffers1,2.  This presentation will describe initial efforts at developing high performance ion exchange adsorbers with other, more traditional ion exchange ligand groups.  Surprisingly, we have discovered that a combination of spacer arm length and spacer arm structure can be used to design new monomers that, when used for membrane surface modification, result in very high efficiencies for protein capture.  These findings may enable the development of large scale bind and elute membrane chromatography.  �Salt tolerant ligands and polymers for membrane absorber applications� Catherine Bothof, Jerald K. Rasmussen, Kannan Seshadri, Amitava Kundu, 241st ACS National Meeting, 2011 , Abstract # BIOT 99.�Development of high performance anion-exchange membrane adsorbers� Jerald K. Rasmussen, Cathy A. Bothof, James I. Hembre, 245th ACS National Meeting, 2013 , Abstract # I&EC 91.

Progress in the development of high performance ion exchange membrane adsorbers

247th National Meeting (2014)

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