Here we describe the synthesis and characterization of a hexameric Mn(II)-based MRcontrast agent. Starting from L-tyrosine, we synthesized an EDTA derivative with a pendant phenol. Reaction of this derivative with N3P3Cl6, followed by deprotection and chelation with Mn(II) gave the rigid, hexameric complex shown. The complex exhibits a high relaxivity (r1 = 6.7 mM-1s-1 (per Mn), 39.3 mM-1s-1 (per molecule), 37�C, 60 MHz, in HEPES buffer) which is much higher than the monomeric analog (r1 = 2.3 mM-1s-1). Here we report the field dependent relaxivity, kinetic inertness, and water exchange properties of this hexameric contrast agent. The intermediate size and high relaxivity make this Mn-EDTA multimer a good candidate for high-field MRI contrast agent applications.

Hexameric Mn(II)-EDTA complex as MRI  contrast agent

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.