According to the American Cancer Society a total of 232,340 new cases and 39,620 deaths from breast cancer are projected to occur in the United States by the end of 2013. There is a dire need for better strategies to prevent, diagnose and treat this deadly disease.  The research efforts in the Rai lab are focused on the use of biodegradable and biocompatible nanoparticles for the prevention and treatment of breast cancer.  In this talk we will present work on using nanoconstructs for both the prevention and treatment of breast cancer. Nanochemoprevention, which involves use of nanoparticles for delivery of chemopreventive agents, is an emerging field that has shown some promise for cancer prevention by improving the bioavailability and reducing toxicity associated with these drugs. We have developed nanometer-sized constructs that encapsulate multiple promising chemopreventive agents and tested their efficacy in cell culture and animal models of breast cancer. From a treatment perspective, theranostic nanoconstructs have also been synthesized, purified, characterized and are being evaluated in cell culture models of breast cancer. Our results from these studies will be presented.

Theranostic nanomedicine for imaging-guided treatment of cancer

247th National Meeting (2014)

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