Here a method developed for the fast release of the liposomes' payload without a significant increase in (local) temperatures is described. This goal is achieved by using the mechanical disruption of the liposomes loaded with magnetic nanoparticles. The mechanical motion of the magnetic nanoparticles locally destabilizes the lipid bilayer resulting in the release of liposomes' payload. The drug release has been tested by two independent assays. The first assay relies on the AC impedance measurements of MgSO4 released from the magnetic liposomes. The second standard permeability assay is based on the increase of the fluorescence signal from 5(6)-Carboxyfluorescein dye when it the dye is released from the magneto liposomes.

Pulsed magnetic field induced fast drug release from magneto liposomes

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.