Vanadium haloperoxidases are known for their ability to oxidize halides using hydrogen peroxide as the oxidant.  Many synthetic analogs of these enzymes have been prepared, which, like the enzyme, catalyze the oxidative bromination of phenol red to bromophenol blue.  As part of a multi-week project in an advanced synthesis laboratory, students were asked to explore the synthesis and reactivity of some of these model complexes.  Unfortunately, significant progress could not be achieved in this limited timeframe because the protocols reported in the literature lack significant detail.  The purpose of this project is to establish and document reliable protocols in order to better understand the system and to assist future students.  One major component of this work is to determine reliable parameters for the catalysis of phenol red to bromophenol blue.  The catalysis would then provide evidence for the validity of the synthesized product.  Progress toward this goal will be presented.

Establishing reliable protocols for the synthesis, characterization, and catalytic activity of model vanadium haloperoxidase complexes

247th National Meeting (2014)

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