In this study three new Ru(II) polypyridyl complexes, [Ru(phen)2(dpphz)]2+ (1 ) (dpphz dipyrido[3,2-a:2',3'-c] phenazine-11-hydrazide, phen = 1,10-phenanthroline), [Ru(bpy)2(dpphz)]2+(2 ) (bpy = 2,2'-bipyridine) and [Ru(dmb)2(dpphz)]2+ (3 ) (dmb = 4,4'-dimethyl2,2'-bipyridine) have been synthesized and characterized. Their DNA binding behavior has been explored by various spectroscopic titrations, viscosity measurements, which indicated that all the complexes could bind to CT-DNA by means of intercalation with different binding strengths. The light switch properties of these complexes have been evaluated. The antimicrobial activities of these three complexes have been investigated. For these complexes Photo induced DNA cleavage studies have been done. All the complexes exhibited efficient photocleavage of pBR322 DNA upon irradiation. The cytotoxicity of these complexes has been evaluated by MTT assay with HeLa tumor cell lines.

Ruthenium(II) polypyridyl complexes synthesis and studies of DNA binding, photocleavage, cytotoxicity activity

247th National Meeting (2014)

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