We disclose the first robust, practical, highly efficient and general H2 hydrogenation catalyst with excellent carbonyl selectivity. The new osmium complexes from our laboratory are today's most successful catalysts facilitating a green reduction process[1-4] affording unsaturated alcohols from the corresponding unsaturated aldehydes, ketones, and esters under H2at 25 � 100 �C, while using 0.01 - 0.05 mol% [Os]. Figure 1.  Catalytic hydrogenation and challenging substrates (Un = olefin-containing group; X = H, R, OR; Y, Z, R = organic fragment or group).References: [1] D. Spasyuk, S. Smith, D. G. Gusev, Angew. Chem. Int. Ed., 2013, 52, 2538.[2] D. Spasyuk, D. G. Gusev, Organometallics, 2012, 31, 5239.[3] D. Spasyuk, S. Smith, D. G. Gusev, Angew. Chem. Int. Ed., 2012, 51, 2772.[4] D. G. Goussev, D. Spasyuk, PCT Patent Application WO 2013/023307 A1.

Selective catalytic C=O hydrogenation of unsaturated aldehydes, ketones, and esters

247th National Meeting (2014)

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