When designing a nanoparticle (NP) system for a specific biomedical application it is necessary to bear in mind that NPs can be coated with a protein biocorona when entering a biological fluid which will determine the mutual cell-  NP interactions and, subsequently, the NPs uptake and trafficking, conditioning their biodistribution and therapeutical response in vivo. Here, we will present different examples showing how the modulation of NP characteristics such as size, shape, surface roughness, or surface functionalization, etc can drastically influence the properties of the protein biocorona, improving NP particle activity by changing the resultant main forces at the nanobiointerface and inducing, at the same time, unexpected biological responses.

Modulation of nanoparticle activity and associated complex biological responses by the nanobiointerface

247th National Meeting (2014)

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