Recent advances in nanotechnology have provided novel strategies to innovate drugs for pharmaceutical development and clinical applications. Bionanotechnology is to utilize the developed technologies and/or materials smaller than 100 nanometers in one dimension and takes advantages of properties that are only presented at this nano level. Nanoscale materials, with their unique size-dependent physical and chemical properties, have showed promising advantages in biological research fields such as intercellular targeted drug delivery, vehicles controlled release of payload, precisely silence of targeted genes, and so on. However, to develop efficient nanomaterials with these promising progresses, the high penetration of plasma membrane and low in vivo toxicology of engineered nanomaterials as drug carriers exist as a potential barrier and has caught much attention. Therefore, Designing nanomaterials for effectively expected effects without significant toxicity has become an important issue for clinical and pharmaceutical application of novel nanobiomaterials. It is critical to screen and identify novel nanomaterials with an exclusive biological function in vitro and in vivo. Recently, innovative materials assembled at nanosize have been developed with negligible cytotoxicity in tissue culture and without detectable side effects in vivo. The unique properties of nanostructures at pharmaceuticals still needs further study by support of scientist with cellular, molecular, materials, biochemical and pharmaceutical background. The developed nanotechnology may inspire researchers to innovate a new generation of nanoscale materials with inventive non-traditional approach to treat various of diseases. The development of nanoscale biomaterials-based structures will allow for more precise efficiently targeted delivery, extended in vivo retention and controllable release behaviors at different levels.

Improved drug delivery efficacy with nanoscale biomaterials�based structures as carriers

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.