During an open surgery, the surgical trauma, hemorrhage, inflammation, and pathogen contamination by surgical procedures may be the main causes for adhesions. And these adhesions could be prevented by several methods such as using a solid barrier. However, the FDA approved products are often incompatible in cases of active bleeding and abdominal infection. Therefore, loading specific drugs in the anti-adhesion membranes is a direct and effective way to solve these problems. Hemostasis agents showed a fast release from blended fibers and an excellent vascular hemostatic efficacy in vivo experiment, while antibiotics showed a relatively slow release from the pure fibers and and out-standing antibacterial effect against the anaerobe. Therefore, double layered fibrous drug carrying membrane could be a good solution for these problem. Facing a serious infection situation, silver nanoparticles (AgNPs) with excellent antibacterial as well as no drug resistance properties could be embeded into pure fibers. The effective dosage was determined by antibacterial experiments in vitro and is much lower than the safe level which was identified in toxicity evaluations. This AgNPs loading membrane could not only be used for preveting adhesion infected operation, but also for preventing implant associated infections, especially the the bacterial colonization after implantation.

Assistant reducing abdominal adhesion and its complication by improved non-woven membranes

247th National Meeting (2014)

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