Fabrication of novel polymeric platforms using well-defined reactive building blocks are becoming increasingly prevalent since control of structure and reactivity at the molecular level can lead to materials with tuneable macroscopic properties. Over the past several years our research has focussed on the design of novel polymeric platforms that allow efficient biomolecular immobilization in a tailored manner using thiol-based conjugations.1 We have designed polymeric materials that allows spatial and temporal control in the immobilization process. As one of the approaches, we have utilized the Diels-Alder cycloaddition-cycloreversion based strategy to access polymeric materials containing thiol-reactive maleimide groups.2 A combination of synthetic reactions with fabrication strategies can be used to obtain three-dimensional reactive polymeric structures with micron and sub-micron features. As an alternative approach, we have expanded the strategy to include other reactive functional groups and building blocks like dendrons to obtain polymeric materials that can be functionalized using metal-free conjugation reactions.3 The presentation will outline several examples where novel molecules are used as building blocks to fabricate polymeric materials with control over chemical and structural properties. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/240nm/uploads/35982_figure_8.jpg' alt='' />References:[1] Kosif, I.; Park, E. J.; Sanyal, R.; Sanyal, A. Macromolecules 2010, 43, 4140.[2] Sanyal, A. Macromol. Chem. Phys.2010, 211,1417.[3] Baradel, N.; Gok, O.; Zamfir, M.; Sanyal, A.; Lutz, J.-F. Chemical Communications 2013, 49, 7280-7282.

Functionalizable polymeric materials: Macromolecular design at the molecular level

247th National Meeting (2014)

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