Nitrosyl hydride (HNO/NO-) is a reactive nitrogen species formed from the 1e- reduction of NO by proteins such as superoxide dismutase and cytochrome c.  HNO has a distinctly separate biological and chemical reactivity from NO. While in vivo generation of HNO has not been indisputably verified, recently others have shown the potential of HNO prodrugs in treating cardiovascular disease, and in preventing ischemia/reperfusion injury and congestive heart failure. Therefore, understanding the chemical reactivity of HNO is of considerable importance. This study investigates the kinetics and mechanism of the reaction between nitrosyl hydride and two phenolic antioxidant compounds: catechol and hydroquinone. Hydroquinone and catechol have significant biological relevance as the main structural units in vitamin K and catecholamine neurotransmitters, respectively. Antioxidants are found in many delectable foods like fruits, vegetables and wine and are known to readily oxidize.

Kinetic and mechanistic studies on the reactions of the reactive oxygen species nitrosyl hydride with the phenolic antioxidants catechol and hydroquinone

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.