Microbial contamination of material surfaces have been problematic in many areas including medical equipment and apparel in hospitals, medical implants, textiles, food packaging and storage, water purification systems and marine equipment. Medical device associated infections significantly contribute to nosocomial infections which have become a devastating and life threatening problem to patients. Bacterial biofilms on medical device surfaces are difficult to eradicate because they exhibit dramatically decreased susceptibility to antimicrobial agents. Despite the presence of efficient surface sterilization techniques there is a great demand for surfaces which can resist bacterial colonization. A major challenge in this field is to develop low-cost antimicrobial materials that kill a broad spectrum of bacteria, but offer significantly low toxicity to human cells. Widely abundant natural resin acids, which are chemically-modified into cationic compounds, efficiently inhibit growth of a wide range of Gram-positive and Gram-negative bacteria, with no or minimal toxicological effects to human cells. We prepared sustainable antimicrobial coatings from resin acids by covalently grafting resin acid derived cationic compounds on to glass surfaces. These contact active coatings exhibited surprising antibacterial properties as well as reduced formation of biofilms. We believe by grafting the surfaces using polymers with pendant cationic moiety will enhance the antimicrobial properties and we can extend the procedure to modify surface of medical devices and implants.References:Khoo, X.; Grinstaff, M. W. Novel infection-resistant surface coatings: a bioengineering approach, MRS Bull. 2011  , 36, 357-366.Campoccia, D.; Montanaro, L.; Arciola, C. R. A review of the clinical implications of anti-infective biomaterials and infection-resistant surfaces, Biomaterials 2013  , 33, 8018-8029.Chen Y.; Wilbon P. A.; Chen Y. P.; Zhou J.; Nagarkatti M.; Wang C.; Chu F.; Decho A. W.; Tang C. Amphipathic Antibacterial Agents Using Cationic Methacrylic Polymers with Natural Rosin as Pendant Group. RSC Adv. 2012  , 2, 10275-10282.Wang J.; Chen Y.; Yao K.; Wilbon P.; Zhang W.; Ren L.; Zhou J.; Nagarkatti M.; Wang C.; Chu F.; He X.; Decho, A. W.; Tang C. Robust Antimicrobial Compounds and Polymers derived from Resin Acids. Chem. Commun. 2012  , 48, 916-918.

Sustainable antimicrobial coatings from resin acids

247th National Meeting (2014)

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