Racemic mixtures of the promising anti-malarial bisindole alkoids, flinderole A � C, desmethyl flinderole C, borreverine and isoborreverine, are baseline separated for the first time by HPLC using vancomycin-based stationary phases and partially separated by capillary electrophoresis (CE) using cyclodextrin selectors. The HPLC results compare the performance of the two commercially available chiral stationary phases (Chirobiotic V and V2) in the polar organic and reversed phase modes and their complementary selectivity is discussed. The performance of the cyclodextrin selectors in CE, while less effective, are discussed in terms of their selectivity in normal and reversed polarity modes.

Enantioseparation of flinderoles and borreverines by HPLC on vancomycin stationary phases and by CE using cyclodextrin selectors

247th National Meeting (2014)

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