Radiosynthesis on a chip is a promising technique for positron emission tomography. However, microscale radiosynthesis of PET tracers on micro fluidic devices need to be further studied to evaluate its usefulness. We examined several micro-scale reactions of [18F]FDG with various reaction conditions to achieve a high radiochemical yield of [18F]FDG. Synthesis of [18F]FDG was performed using mannose triflate on a microchip, and the crude product was purified via cartridge purification. The reaction conditions were optimized by examining several factors including reaction solvents, and bases that influence microscale radiosynthesis of [18F]FDG. Based on the investigation of several variables and their effects on the radio-synthetic reaction, [18F]FDG was successfully synthesized on a micro-scale level with a radiochemical yield of 71% (n = 7), and within a shorter time frame than that of the traditional method. These results show that the new guidelines provide a more efficient method of microscale [18F]FDG radiosynthesis. 

Efficient and high yield microscale synthesis of [18F]-2-fluoro-2-deoxy-D-glucose

247th National Meeting (2014)

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