Nitroxyl (HNO), the one-electron reduced and protonated cousin of nitric oxide (NO), has recently received significant attention as a novel biological agent with unique pharmacological properties.  Given its inherent reactivity, HNO cannot be used directly.  Donor molecules are required for the generation of HNO in situ, but unfortunately relatively few precursors to HNO exist.  The most commonly used HNO donor is Angeli's salt, a compound that has been known since 1896.  That same year, another HNO donor, Piloty's acid, was also reported.  In the intervening century, only a very small number of other HNO donors suitable for use under physiological conditions have been developed.  This presentation will focus on our recent work in this area.

Development of new physiologically useful nitroxyl (HNO) donors

247th National Meeting (2014)

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