Our research is focused on the development of new transition-metal catalyzed reactions employing non-traditional electrophiles to enable efficient preparation of highly enantioenriched products. We have developed enantioselective, copper-catalyzed alkynylations of oxocarbenium ion intermediates and enantiospecific, nickel-catalyzed cross couplings of amine- and alcohol-derived alkyl electrophiles with organoboranes. The development and scope of these transformations will be presented, along with our mechanistic hypotheses and stereochemical proposals.

Cross coupling reactions of non-traditional electrophiles

247th National Meeting (2014)

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