As starch derivatives, �-cyclodextrin (�-CD) has received increasing attention due to its special chemical structure and excellent properties. In this work, a novel �-CD based on N-halamine antimicrobial copolymer (�-CD-MAH-VBDMH) was synthesized and characterized by solid-state 13C NMR spectroscopy. The electrospun nanofibers were obtained using mixed solution of �-CD-MAH-VBDMH and cellulose acetate (CA). The obtained nanofibers were characterized by SEM, XRD, TGA, and DSC. After chlorination treatment by sodium hypochlorite, biocidal efficacies of chlorinated nanofibers against Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895) were determined using a modified AATCC 100-1999 method. The fibers showed excellent antimicrobial properties against these two bacterial species within brief contact times. UVA irradiation tests indicated that the chlorine bound to the fibers is relatively stable, and most of the lost chlorine could be recovered by re-chlorination. The mouse 3T3 fibroblasts in vitro cell cytocompatibility studies demonstrated that the antibacterial nanofibers have good biocompatibility.

Cytocompatible antimicrobial nanofibers based on �-cyclodextrin derivative N-halamine copolymers

247th National Meeting (2014)

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