This work reports release studies of acetylsalicylic acid (Aspirin), a model drug from electrospun ArbomatrixTM {a block copolymer with arborescent polyisobutylene (PIB) core and poly (para-methyl styrene) PMS end blocks} polymer fiber mats. ArbomatrixTM �PEG polymer solutions containing 15 and 30 wt% Aspirin were electrospun onto parchment paper to yield free-standing rubbery fiber mats. Aspirin release into phosphate buffered saline (PBS) solution (pH = 7.4) at 37oC was measured by UV spectroscopy.  In three days 42 and 90% of the loaded Aspirin was released from the mats containing 15 and 30wt% Aspirin, respectively. Due to the excellent biocompatibility of ArbomatrixTM these mats hold great promise for drug delivery applications.

Drug eluting electrospun rubbery fiber mats

247th National Meeting (2014)

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