Despite significant promise of nanomaterials in medicine, few colloidal materials make the transition into the realm of clinical applications. In this presentation a novel class of multifunctional fluorescent silica-based core-shell nanoparticles will be introduced referred to as �Cornell dots� or simply �C dots�. These particles have sizes below 10 nm, which is below the threshold for renal clearance, leading to favorable biodistributions. These smaller than 10 nm sized PEGylated labels for nanomedicine are the first dual-modality (optical/PET) hybrid nanoparticles of its class and properties receiving investigational new drug (IND) FDA approval for first in-human trials in the US. In this presentation, after shortly reviewing results on C dot synthesis, characterization, optical properties and animal studies, first results will be reported on clinical trials with human melanoma patients assessing particle safety. Subsequently work towards employing these probes in sentinel lymph node mapping will be described in which a specific camera system was developed that surgeons can use for visualization of nodes during surgery. These efforts recently also lead to FDA IND approval for a new clinical trial now open for patient recruitment. References:1.) M. S. Bradbury, E. Phillips, P. Montero Miranda, S. M. Cheala, H. Stambuk, J. C. Durack, C. T. Sofocleous, R. J. C. Meester, U. Wiesner, S. Patel, Clinically-Translated Silica Nanoparticles as Dual-Modality Cancer-Targeted Probes for Image-Guided Surgery and Interventions, Integr. Biol. 5  (2013), 74-86.2.) M. Benezra, O. Penate-Medina, P. B. Zanzonico, D. Schaer, H. Ow, A. Burns, E. DeStanchina, V. Longo, E. Herz, S. Iyer, J. Wolchok, S. M. Larson, U. Wiesner, M S. Bradbury, Multimodal silica nanoparticles are effective cancer-targeted probes in a model for human melanoma, J. Clin. Invest. 121  (2011), 2768�2780.

Cornell dots as a new class of fluorescent nanoparticles to improve visualization in cancer surgery

248th National Meeting (2014)

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