Biodegradable polymer nanoparticles (NPs) hold great promise as they have demonstrated significant results in multiple pathologies. However, their precise functionalization in oder to confer them with fluorescence (for tracing purposes) and targeting abilities is still a challenge.Herein is reported the design of two different classes of multifunctional (i.e., PEGylated, fluorescent and targeted) nanoparticles based on either poly(alkyl cyanoacrylate) (PACA) or poly(lactic acid) (PLA), two major biodegradable polymers, and their successful in vitro application to two major pathologies: Cancer and Alzheimer's disease (AD).The functionalization strategy relied on the robust 'click' coupling between the polymer scaffold and the ligand of interest. For Cancer, we used biotin, folic acid or anisamide as ligands and regarding AD, we functionalized the NPs with either a curcumin derivative or a novel antibody in order to bind the �-amyloid peptide 1-42 (A�1-42), a major biomarker of AD.The synthetic pathway is thus very versatile and can be applied to a broad range of pathologies, simply by adjusting the surface decoration of the nanocarriers.

Novel multifunctional polymer nanoparticles for active targeting in drug delivery: Application to cancer and Alzheimer's disease

248th National Meeting (2014)

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