The goal of this work is the controlled long term release of bone morphogenetic protein 2 (BMP-2) from polyelectrolyte multilayer coatings so as to improve osseointegration and durability of titanium implants. Polyelectrolyte multilayer coatings were prepared from solutions of poly(methacrylic acid) and poly-L-histidine. BMP-2 was adsorbed to the surface of anodized titanium and polyelectrolyte multilayer coatings were built up on top of the BMP-2. The effect of deposition conditions on coating properties and BMP-2 release, as well as preosteoblast response to these parameters, was investigated. Polyelectrolyte multilayers prepared under natural conditions to those prepared from solutions at an acidic pH and solutions containing salt. High levels of BMP-2 release were achieved. Enhanced preosteoblast differentiation was observed on coatings prepared from modified solutions; however, this increased differentiation was apparent for both BMP-2-eluting and control coatings. Additionally, a positive relationship between surface roughness and differentiation was observed, which may account for increased differentiation for systems that do not release BMP-2. The effects of both BMP-2 release and surface roughness on preosteoblast response are investigated and proposed methods of adjusting these properties independently will be explored.

Effect of polyelectrolyte multilayer deposition conditions on growth factor release and preosteoblast behavior

248th National Meeting (2014)

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