New late stage fluorination methods hold the promise of enabling new PET radiotracer discovery. How many of these methods do we really need? Are we designing the right methods for use in fluorine-18 chemistry? Using examples from collaborative efforts with my research lab, I will discuss the adaptation of new fluorine-19 chemistry for use in fluorine-18 radiochemistry. I will highlight unanticipated difficulties encountered in fluorine-18 chemistry and provide perspective on how to best use new reaction methodology in radiotracer discovery. The presentation will feature two main examples: 1) Ni-mediated fluorinations and their use in the synthesis of [18F]MDL-100,907 and [18F]5FU; 2) Mn(salen)-mediated benzylic and aliphatic fluorinations through sp3 C-H bond replacement and their use in high-throughput radiotracer synthesis.

PET radiotracer development using modern late-stage fluorination

248th National Meeting (2014)

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