The development of synthetic methodologies for the preparation of complex, functional polymer materials by simple strategies has enormous potential for biomedical applications. Here, two degradable nanoparticle systems based on one alkyne-functionalized polyphosphoester and their broad applicability in treating diseases, such as pulmonary cancers, infections and injuries, will be discussed. The highly water-soluble backbone of the polyphosphoester endowed the first system with ultrahigh paclitaxel loading capacity (55 wt%) and a maximum paclitaxel Concentration of 6.2 mg/mL in water, for the treatment of lung cancers. In the second system, the easily functionalizable side-chain of the polyphosphoester allowed for the preparation of a family of nanoparticles with diverse surface charge types, non-ionic, anionic, cationic and zwitterionic, in a rapid and versatile manner. The anionic nanoparticles are designed to load silver ions to treat pulmonary infections, while the cationic nanoparticles are being applied to regulate lung injuries by their degradation products.

Rapid and versatile construction of polyphosphoester-based nanostructures designed for various biomedical applications

248th National Meeting (2014)

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