Almost 10 years ago, the theory HIV latency is a stochastic phenomenon was first proposed (Weinberger et al. Cell, 2005). Subsequent studies established the HIV-latency circuit as one of the leading examples of stochastic decision-making in biology and recent studies indicate that stochastic gene expression may be the most problematic barrier to efficient HIV latency reactivation in patients (Ho et al. Cell, 2013; Weinberger & Weinberger, Cell, 2013). I will present new evidence on the molecular mechanism of stochastic HIV expression. The mechanism suggests novel approaches to manipulate the stochastic decision to either purge the HIV latent reservoir or shunt all virus into the latent reservoir for long-term viral 'containment' therapy.

Regulation of HIV latency by stochastic noise in gene expression

248th National Meeting (2014)

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