Due to its extraordinary physical and chemical properties, graphene and its derivatives have made great development in the field of biomedicine research. The construction of safe and efficient nano-graphene drug carries is still a hot topic. Herein, we would like to report a nanosupramolecular assembly (GO-CD-HA) which is fabricated through the noncovalent multiple interactions between the �-cyclodextrin-modified graphene oxide (GO-CD) and adamantane-bearing hyaluronic acid (HA-ADA). Compared with GO-CD, GO-CD-HA nanosupramolecular assembly showed increased solubility and stability under physiological environment. The size distribution of GO-CD-HA is 50~150 nm. Significantly, camptothecin (CPT), a water-insoluble anticancer drug, can be loaded onto GO-CD-HA through p�p stacking and hydrophobic interaction, and then continuously released in vitro.  Figure  1.  Construction of GO-CD-HA-CPT conjugates, AFM images (a, b) and UV/vis spectra (c) of GO-CD-HA and GO-CD-HA-CPT, and fluorescence spectra (d) of CPT and GO-CD-HA-CPT.We thank 973 Program (2011CB932502) and NNSFC (91227107) for financial support.References 1.   Yang, K.; Feng, L.; Shi, X.; Liu, Z. Chem. Soc. Rev. 2013 , 42, 530-547.2.   Yang, Y.; Zhang, Y.-M.; Chen, Y.; Zhao, D.; Chen, J.-T.; Liu, Y. Chem. Eur. J.  2012 , 18, 4208-4215.3.   Pan, Y.; Bao, H.; Sahoo, N. G.; Wu, T.; Li, L. Adv. Funct. Mater. 2011 , 21, 2754-2763.

Hyaluronic acid-conjugated graphene nanosupramolecular assembly for drug targeting and controlled release

248th National Meeting (2014)

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