On the basis of successful development of novel plant elicitor, methiadinil, by registration in China, aimed at the key insect and disease management, several kind of chemical diversity of N and S containing novel heterocyclic pro-elicitor derivatives with both systemic acquired resistance and insecticide or fungicide activity were designed and synthesized. Partial target molecules designed and synthesized are shown in Figure 1. Bioassay results indicated that, the highly active target compounds kept their fungicide or insecticide activity, while their metabolites played a key role as of plant elicitor. Preliminary studies on the mode of action proved their systemic acquired resistance based pesticide activity. Our studies provided an integrated new method for plant protection.

Systemic acquired resistance-based novel pesticide development

248th National Meeting (2014)

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