Marine mussel uses adhesive proteins to attach itself to substrates. Previously, we demonstrated that complex coacervation (liquid-liquid phase separation via concentration) was successfully formed using recombinant mussel adhesive proteins (rMAPs) as positive partners and hyaluronic acid (HA) as a negative partner. We found that highly condensed and non-water dispersed rMAP/HA-based complex coacervates significantly increased the bulk adhesive strength of rMAP in both dry and wet environments. In addition, we determined that rMAP/HA-based complex coacervates have very low interfacial tension values around 0.2-0.3 mN/m. Here, we will present several applications of rMAP/HA-based complex coacervates in tissue and biomedical engineering fields.

Complex coacervates based on mussel adhesive protein and hyaluronic acid for tissue and biomedical engineering

248th National Meeting (2014)

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